Chalcones can be prepared through condensation of 4-hydroxyl acetophenone or 2,4-dihydroxyl acetophenone with substitued benzaldehydes in ethyl glycol solution, using the catalyst of boric acid at 110~ 120 ℃ in 6 h. The product was purified by the flash chromatography on silica gel. 4羟基苯乙酮或2,4二羟基苯乙酮与取代苯甲醛在乙二醇溶液中,以硼酸为催化剂,于110~120℃反应6h,再经柱分离精制得羟基查尔酮衍生物。